Synthetic vs Natural: How Long Does Testosterone Stay In Your System?

Testosterone holds a lot of responsibilities for many essential functions in the body so it's no strange thing that looking for ways to infuse this into our system is something that people—both men and women—look into especially at certain ages.

Whether you are dealing with low energy, a decrease in muscle mass, or a drop in libido, understanding how testosterone works and how long it stays in your system shouldn't be overlooked.

Synthetic Vs Natural Testosterone

First, let's take a look at the two main types of testosterone: synthetic and natural.

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Natural testosterone, as the name suggests, is the hormone that is produced internally by the body. In men, this is produced mainly by the testes, while in women, the production lies in the ovaries and adrenal glands. This hormone is responsible for regulating:

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• Libido
• Bone mass/health
• Fat distribution
• Muscle mass
• Red blood cell production
• Sperm production
• Fertility (in women)
• Menstrual production (in women)

Synthetic testosterone, on the other hand, is manufactured and inserted into the body via injections, gels, patches, or pills. These are often utilized in testosterone replacement therapy (TRT) as a way to combat low testosterone levels, a condition we call hypogonadism. But while synthetic testosterone effectively raises hormone levels, it can also introduce potential side effects and risks to your body.

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How Long Does Testosterone Stay In Your System?

How long testosterone stays in your system typically depends on various factors, especially when it's a synthetic one. By default, natural testosterone has a relatively short half-life and is regulated by the endocrine system, so its levels fluctuate throughout the day—typically peaking in the morning and gradually decreasing by evening.

For synthetic testosterone, the duration of it in the system varies based on the form and method of administration:

Injectable Testosterone

Modified injectable testosterone are called testosterone esters, and this version has been altered to last for days or even weeks in the body.

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The modified versions are:

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Transdermal Patches

These patches are worn on the skin, typically on the arm or upper body. They release testosterone steadily into your bloodstream and need to be applied daily. The testosterone from patches can stay in your system for about 24 hours, so daily application is a necessity if you want to reap the full effects.

Gels

Testosterone gels come in a foil packet, pump, or twist-off bottle. They are applied once a day, often on the shoulders, upper arms, or thighs. The testosterone from gels can be detected in your system for approximately 24 hours, so it requires daily application. The nasal gel, applied three times a day, ensures a consistent level of testosterone in your system throughout the day.

Testosterone Mouth Patch

This patch looks like a pill but sticks to your upper gums, releasing testosterone continuously through the oral tissues. The testosterone from these patches remains in your system for about 12 hours, requiring the patch to be replaced twice daily.

Testosterone Implants

These are small pellets inserted under the skin, usually in the buttocks area, every 3 to 6 months. Testosterone from these implants is gradually released into your bloodstream and can remain effective in your system for up to 3 to 6 months.

Oral Testosterone

Oral testosterone formulations, such as Jatenzo, Tlando, and Kyzatrex, have a shorter half-life and need to be taken more frequently to maintain stable levels. They are typically metabolized quickly, staying in your system for about 12 hours, requiring twice-daily dosing with food.

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How Can I Increase My Testosterone And Last Longer?

Boosting testosterone levels naturally can be accomplished through lifestyle changes, diet, and supplements. Here are some effective strategies:

Get Moving with Exercise

Regular exercise is one of the best ways to boost your testosterone. Weight lifting and high-intensity interval training (HIIT) are particularly effective. These activities don’t just help you build muscle and shed fat; they also stimulate hormone production. So, grab those dumbbells or hit the track for some sprints—you’ll feel more energetic and stronger in no time.

Eat Right

Make sure you're getting plenty of proteins, fats, and carbs—lean meats, fish, eggs, nuts, and seeds are all great options! These foods provide the nutrients your body needs to produce testosterone naturally. Plus, eating well keeps you feeling good overall, which is a bonus.

Prioritize Quality Sleep

Aim for 7-8 hours of uninterrupted sleep each night—this will help your body maintain a healthy hormone balance, including testosterone levels. So, turn off the screens a little earlier, create a relaxing bedtime routine, and give your body the rest it needs.

Manage Stress

Chronic stress is a testosterone killer because it raises cortisol levels, which can negatively impact hormone production. Practices like meditation, deep breathing exercises, and yoga can be very effective—even taking a few minutes each day to relax and unwind can make a significant difference.

Consider Supplements

While lifestyle changes are the foundation, certain supplements can also help. Vitamin D, zinc, and magnesium are known to support testosterone production. However, it’s important to talk to a healthcare provider before starting any supplements to ensure they’re right for you.

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How Long Do You Have To Take Testosterone For It To Be Permanent?

Testosterone therapy isn’t usually a lifelong commitment for everyone. How long you need to take testosterone depends on why you're using it and how your body responds. 

For some people with conditions like hypogonadism, where the body can’t produce enough testosterone on its own, therapy might be necessary for life to keep testosterone levels normal.

If you stop testosterone therapy, symptoms of low testosterone might come back if the original issue hasn't been fixed. Some changes from the therapy, like increased muscle mass or more body hair, might stick around even after you stop. 

However, without continued treatment, your hormone levels and the benefits you’ve experienced will gradually fade.

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Conclusion

Knowing how long testosterone stays in your system, whether from natural or synthetic sources, helps in making informed decisions about your health regimen—remember, balanced hormone levels can greatly enhance your quality of life. Do ensure that you are doing regular check-ups and hormone level monitoring for you to reap the benefits of testosterone without any harmful side effects.

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Optimize Your Health with Craft Men’s Clinic

Want to know more about how testosterone influences your growth and overall health? At Craft Men’s Clinic, our experts are here to offer personalized advice and plans tailored just for you. 

We’ll help you understand the role of testosterone in everything from muscle growth to mood improvement. Book a consultation today and take the first step towards a healthier, more vibrant you. Let’s work together to optimize your health and performance!

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